The purpose of this study is to provide comprehensive understanding of logic and reason of Islamization of Knowledge (IOK), as an intellectual response from Muslim Scholars to what so called “ Modernity Project” in recent decades. Using Meta-Analysis as a method of study, this research systematically has reviewed over 80 scientific documents including articles, books, reviews and etc. in order to come out with a clear picture and understanding of reason and logic of Islmization of Knowledge across the world. Having such understanding and clear picture of reason and logic of IOK, with its main categories, trends and pertinent comparative studies as well as their strength and weaknesses will help and guide Muslim scholars and thinkers in their future studies along the path toward restore their supremacy in knowledge. The result of the study shows that Islamization of knowledge emerged within the context of the perceived crisis of Islamic civilization and concomitant crisis the intellectuals.